Gene information
Official symbol CXCL8
Official full name C-X-C motif chemokine ligand 8
Gene type protein-coding gene
Chromosome4q13.3
Alias symbolSCYB8; LUCT; LECT; MDNCF; TSG-1; IL-8; NAP-1; 3-10C; MONAP; AMCF-I; LYNAP; NAF; b-ENAP; GCP-1; K60; GCP1; NAP1
Previous symbolIL8
Gene familyChemokine ligands; Interleukins
Resources
Entrez Gene 3576
HGNC HGNC:6025
Ensembl ENSG00000169429
Vega OTTHUMG00000151316
GO terms: 97 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006898 receptor-mediated endocytosis GO Biological Processes -6.77623895 13 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008277 regulation of G protein-coupled receptor signaling pathway GO Biological Processes -5.69311965 11 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031623 receptor internalization GO Biological Processes -4.60359151 7 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036230 granulocyte activation GO Biological Processes -5.56986570 6 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042119 neutrophil activation GO Biological Processes -4.98581398 8 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0043903 regulation of biological process involved in symbiotic interaction GO Biological Processes -3.29518609 9 More
GO:0044344 cellular response to fibroblast growth factor stimulus GO Biological Processes -7.12681878 10 More
GO:0045069 regulation of viral genome replication GO Biological Processes -1.96545001 9 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO Biological Processes -4.37747366 6 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048565 digestive tract development GO Biological Processes -11.5666667 27 More
GO:0048566 embryonic digestive tract development GO Biological Processes -4.28720299 8 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0050792 regulation of viral process GO Biological Processes -4.90676471 20 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0050927 positive regulation of positive chemotaxis GO Biological Processes -14.3403642 15 More
GO:0050930 induction of positive chemotaxis GO Biological Processes -11.6499260 8 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0052372 modulation by symbiont of entry into host GO Biological Processes -2.32945221 7 More
GO:0055123 digestive system development GO Biological Processes -12.1524002 29 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060353 regulation of cell adhesion molecule production GO Biological Processes -7.13135320 9 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071622 regulation of granulocyte chemotaxis GO Biological Processes -10.3031127 11 More
GO:0071624 positive regulation of granulocyte chemotaxis GO Biological Processes -4.01585848 7 More
GO:0071774 response to fibroblast growth factor GO Biological Processes -7.87961599 11 More
GO:0090022 regulation of neutrophil chemotaxis GO Biological Processes -5.21154381 9 More
GO:0090023 positive regulation of neutrophil chemotaxis GO Biological Processes -3.41852381 6 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1902622 regulation of neutrophil migration GO Biological Processes -4.86040077 10 More
GO:1902624 positive regulation of neutrophil migration GO Biological Processes -3.51698265 7 More
GO:1903900 regulation of viral life cycle GO Biological Processes -3.59662203 16 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 30 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04218 Cellular senescence KEGG Pathway -5.14633043 11 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05120 Epithelial cell signaling in Helicobacter pylori infection KEGG Pathway -1.87202281 4 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05161 Hepatitis B KEGG Pathway -5.78517620 12 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05219 Bladder cancer KEGG Pathway -8.60591296 9 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 56 records
Drug name Interaction type Source PMID View
abx-il8 inhibitor ChemblInteractionsTTD view
acetaminophen NCI 15878691 view
aldrin DTC view
alprazolam NCI 12218154 view
aspirin NCI 12576442 view
bevacizumab PharmGKB 23584701 view
broxuridine DTC view
canertinib NCI 15956251 view
ceftriaxone NCI 8011012 view
cetuximab NCI 106147161590866410037173 view
chembl1579130 DTC view
chembl1902074 DTC view
chlordane DTC view
cidofovir NCI 10630964 view
clarithromycin NCI 12003967 view
colchicine DTC view
coronopilin DTC view
dacarbazine DTC view
danazol NCI 16161451 view
dichlorvos DTC view
dicyclohexylcarbodiimide DTC view
dinitro cresol DTC view
dipyridamole NCI 10660968 view
e319 DTC view
emodin DTC view
endosulfan DTC view
fenretinide NCI 16979119 view
fentanyl NCI 9527747 view
foscarnet NCI 10630964 view
harmine hydrochloride DTC view
heptachlor DTC view
humax-il8 inhibitor ChemblInteractions view
hydroquinone DTCNCI 17118622 view
ibuprofen TTD view
ionomycin NCI 7510691 view
lansoprazole NCI 17122965 view
leflunomide NCI 10902750 view
methimazole NCI 11453524 view
midazolam NCI 9620522 view
naproxen NCI 11852880 view
omeprazole NCI 17122965 view
paclitaxel NCI 9271387 view
pamidronic acid NCI 12006522 view
pentoxifylline NCI 12576442 view
pyrogallol DTC view
questiomycin b DTC view
retinal DTC view
retinol DTC view
ribavirin DTC view
sunitinib PharmGKB 26387812 view
talc NCI 17000556 view
terfenadine NCI 8919641 view
tretinoin NCI 8900181 view
troglitazone NCI 12364456 view
verapamil NCI 2686646 view
yangonin DTC view
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
interleukin-8 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Jadhav PP et al. J Assoc Physicians India. 1994
interleukin-8 proteomics complication[prognosis (bad)] acute ST elevation myocardial infarction Riesenberg K et al. Eur J Clin Invest. 1997
interleukin-8 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kameda K et al. Circ J. 2006
interleukin-8 proteomics ventricular septal rupture[prognosis (bad)] acute myocardial infarction Kameda K et al. Circ J. 2006
interleukin-8 proteomics ventricular fibrillation[prognosis (bad)] acute ST elevation myocardial infarction Elmas E et al. Clin Chem Lab Med. 2007
interleukin-8 proteomics good predictor death[prognosis (bad)] acute myocardial infarction Prondzinsky R et al. Clin Res Cardiol. 2012
interleukin-8 proteomics myocardial infarction[diagnosis] myocardial infarction Velasquez IM et al. Int J Cardiol. 2014
interleukin-8 proteomics left ventricular wall motion score index[other] acute ST elevation myocardial infarction Husebye T et al. PLoS One. 2014
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